Takahashi Tetsuo, a biology teacher at Shizaki High School, has been fascinated with "demi-humans," beings with characteristics that differ just slightly from humans, since he was in college. He wishes he could have a chance to talk with one, but since the demi-human population is fairly low, he's never even met one. But then the school gains a new math teacher, Satou Sakie... who happens to be a succubus.
The story takes place in an age where "Ajin" (demi-human), more casually known as "Demi," have slowly started to become accepted into human society. Tetsuo Takahashi is a biology teacher who ends up teaching three such Demi, hoping to understand more about them while also managing to catch their attention.
