Futaba is chosen as a program-reg, a voice actress who regularly voices bit parts, in a western anime starring Ryoko Shiraishi. After the first day of recording, Futaba's throat starts acting up from the intense bit part she played, and has to miss a week of recording after getting a cold. While walking home with Futaba the week afterwards and hearing about her determination to keep up with Ichigo and Rin, Shiraishi explains how she got vocal cord nodules from pushing herself too hard and needed throat surgery. Later, as Earphones gets its first solo concert booked, Ichigo takes on the task of choosing and choreographing cover songs to fill the concert's runtime, while everyone also has to try and promote the concert in order to fill their venue. Just as things are progressing, Ichigo ends up spraining her ankle.
The series is centered on three friends who are all rookie voice actresses; Futaba Ichinose, Ichigo Moesaki and Rin Kohana. As the girls go through their individual troubles of working in voice acting, they end up hosting a web radio show together and form the unit, Earphones.
