Six months ago while in S-city, Black Jack saves Rei Fujinami, one of four girls who is injured while ice skating. Now, during a stop-over in S-city, he encounters the same girl who asks him to treat Yumiko Inoue (Rei's friend) who is in a coma after an 80m fall. Of her other friends, Yuki was killed by a speeding car and Kaori committed suicide 10 days later. Jack examines Yumiko in the wealthy private hospital inherited by Tokio Umetani, although Umetani is more interested in car racing. Jack operates on Yumiko to remove the hematoma on her brain, assisted by the hospital surgical team. Jack discovers that the girls became addicted to mescaline from a small, spiny cactus after finding them growing on Mt. Senin and informs his friend, Police Lt. Takasugi. He accuses Umetani of cultivating the plants and attempting to kill the girls to hide his secret, however they are suddenly interrupted by syndicate operatives who abduct them. They are left on Mt. Senin with the plants ablaze and a ticking time bomb, however Jack just manages to drag himself and Umetani free before the explosion. Later, he bids a fond farewell to Rei and Takasugi.
Kuroo Hazama, also known as "Black Jack," is a legend in the medical world. Famous for being one of the best, as well as not having a license, Hazama and his assistant Pinoko save countless lives that other doctors cannot... for a price; an exorbitant price, in fact, which causes many to view the genius as greedy and heartless. Despite these claims, however, none can deny his skill and the lengths that he will go to treat his patients. This dark medical drama tells the story of the ominous and mysterious world of underground medicine as Black Jack risks his life to cure some of the most bizarre diseases imaginable, even if it means breaking every law in the process.
