While on vacation, Black Jack comes across a young man called Leslie Harris on a train. Bullet wounds mysteriously appear on his body, bleed, but then disappear. Leslie has recurring dreams of seeing a woman with a child singing about the Owl of San Merida where he finds himself in a battle zone being shot. Black Jack examines him and finds barely visible signs of many earlier operations. They travel to the Republic of El Garnia, a country with over 25 years of civil war which ended 4 years earlier, and visit the village of San Merida. Leslie finds it familiar, and they meet Ernesto, the only survivor who tells the story of how he, an uncertified doctor, saved a baby by using the blood and body components of the dead woman Sanda, including her bullet-riddled skin. Suddenly the government troops arrive and arrest, then summarily shoot Ernesto for his part in the resistance. Jack is unable to save his life, leaving Leslie the only living survivor of San Merida.
Kuroo Hazama, also known as "Black Jack," is a legend in the medical world. Famous for being one of the best, as well as not having a license, Hazama and his assistant Pinoko save countless lives that other doctors cannot... for a price; an exorbitant price, in fact, which causes many to view the genius as greedy and heartless. Despite these claims, however, none can deny his skill and the lengths that he will go to treat his patients. This dark medical drama tells the story of the ominous and mysterious world of underground medicine as Black Jack risks his life to cure some of the most bizarre diseases imaginable, even if it means breaking every law in the process.
