10 hours before the Flying Pussyfoot departs, in California, Russo learns that his cash was stolen by a couple and one of his underlings was killed. Then Ladd barges in and shows Russo just how much of a homicidal maniac his before heading to the Flying Pussyfoot with his subordinates. Back to the Flying Pussyfoot, Vicky has been killed by the "Lemurs" and yet again Ladd shows how much of a maniac he is. In New York Isaac and Miria happily enter the hat shop and after their purchase they are hit by the car Ennis is driving. She happens to be chauffeuring Szilard to the secret society of old geezers.
During the early 1930s in Chicago, the transcontinental train, Flying Pussyfoot, is starting its legendary journey that will leave a trail of blood all over the country. At the same time in New York, the ambitious scientist Szilard and his unwilling aide Ennis are looking for missing bottles of the immortality elixir. In addition, a war between the mafia groups is getting worse. On board the Advena Avis, in 1711, alchemists are about to learn the price of immortality.
