In 1931 onboard the Flying Pussyfoot, Issac and Miria realize that they forgot to get Ennis a souvenir and Jacuzzi, Nice, Donny and Nick decide to search for the Rail Tracer. In New York in 1930, whilst Eve is crying over her missing brother she overhears Isaac and Miria's supposedly "quiet" conversation and goes out to investigate. After a while Eve begins to enjoy their company and even tells them about her brother Dallas, so in their way of helping Isaac and Miria decide to rob the Genoard family assets. On the Flying Pussyfoot, Jacuzzi and co. discover that their friends are missing so he instructions them to split up into 2 groups to search for them.
During the early 1930s in Chicago, the transcontinental train, Flying Pussyfoot, is starting its legendary journey that will leave a trail of blood all over the country. At the same time in New York, the ambitious scientist Szilard and his unwilling aide Ennis are looking for missing bottles of the immortality elixir. In addition, a war between the mafia groups is getting worse. On board the Advena Avis, in 1711, alchemists are about to learn the price of immortality.
